Everything about Amphotericin B Medication

Amphotericin B is an antifungal drug used for severe fungal infections and leishmaniasis. Fungal infections used to treat it include aspergillosis, blastomycosis, candidiasis, coccidioidomycosis, and cryptococcosis. Currently, it is in demand due to various Fungal Infections like Black Fungus, White Fungus, and Yellow Fungus in the COVID-19 pandemic.

How To Use Amphotericin B Vial

This medicine is usually given by injection into a vein as directed by your doctor, usually once a day or every other day. It should be injected slowly over 2 to 6 hours. Your doctor may first give you a small dose to test your response to the drug. The dosage is based on your medical condition, weight, test dose-response, and medical response. If this medicine remains off for 7 days or more, it should be resumed at the lowest dose and gradually increased.

If you are giving this medicine to yourself at home, know all the preparation and use instructions from your health care professional. Before use, visually check this product for particles or discoloration. If any is present, do not use the liquid. Learn how to safely store and discard medical supplies.

It may be necessary to continue this medicine for several weeks to several months to treat some infections. Discontinuation of the drug too early may cause a withdrawal of the infection. Tell your doctor if your condition persists or worsens. Right now it is in demand due to fungal infections like Mucormycosis in COVID-19.

Side Effects 

  • Fever, shivering, chills, flushing,
  • Loss of appetite, dizziness, nausea, vomiting.
  • Shortness of breath or rapid breathing may occur 1 to 3 hours after the start of the infusion.
  • In some cases, other medications (including acetaminophen, diphenhydramine, corticosteroids such as hydrocortisone) may be necessary to prevent or relieve these side effects.
  • If any of these effects persist or worsen, tell your doctor or pharmacist immediately.

Remember that your doctor has prescribed this medication because he has decided that the benefit to you outweighs the risk of side effects. Many people using this medicine do not have serious side effects.

Serious Side Effects

  • Swelling and pain at the injection site.
  • Muscle or joint pain,
  • Abnormal Fatigue, Weakness, Muscle Spasms,
  • Signs of kidney problems (such as urinary volume Changes, pain) urination)
  • Numbness or tingling of hands, feet,
  • Changes in vision,
  • Changes in hearing (eg, ringing in ears),
  • Dark urination,
  • Severe abdominal pain
  • Yellowing of eyes skin,
  • Swelling on ankles or feet,
  • Rapid/slow/irregular heartbeat,
  • Cold sweats,
  • Blue lips,
  • Bleeding, other signs of infection (eg, fever, persistent sore throat),
  • Mental or Mood Changes, Seizures,
  • black stools, vomit that looks like coffee grounds.

A very severe allergic reaction to this drug is rare. However, if you notice symptoms of a severe allergic reaction, seek immediate medical attention, including rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

Also read: Myalgia| what causes muscle pain

Note- This is not a complete list of possible side effects. If you do not see other effects listed above, contact your doctor or pharmacist.

Precautions

Before using amphotericin, consult your doctor or pharmacist if you are allergic to it; Or if you have any other allergies. This product may contain inactive ingredients, which may cause allergies or other problems for you. Talk to your pharmacist for more details to keep yourself safe.

Before using this medicine, tell your doctor or pharmacist your medical history, in particular: white blood cell (leukocyte) transfusion, heart disease (eg, irregular heartbeat, congestive heart failure), liver or kidney disease. During pregnancy, this medicine should be used only when only needed. Discuss the risks and benefits with your doctor.

Risk Factors 

The drug’s risk factors can change how your medications work or may increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription, nonprescription drugs, and herbal products) and share it with your doctor and pharmacist. Never start, stop, or change the dose of any medicine without your doctor’s advice or approval.

Some products that may interact with this drug include anti-cancer drugs (For ex- mechlorethamine, nitrogen mustard), azole antifungals (e.g., ketoconazole, itraconazole), cidofovir, digoxin, flucytosine, medications that affect the kidneys (including pentamidine, tacrolimus, aminoglycosides such as gentamicin), muscle relaxants ( tubocurarine), zidovudine.

Amphotericin B Important Factors

Medical Test-  Laboratory or medical tests (eg, kidney and liver function tests, potassium and magnesium levels, complete blood count) should be done according to schedule to monitor your progress or check for side effects. Consult your doctor for more details.

Missed Dose- For the best possible benefit, it is important to receive each prescribed dose of this medicine as directed. If in case you miss a dose, contact your doctor or pharmacist immediately to establish a new dosing schedule. Don’t double the dose to catch up that day.

Storage- Consult product instructions and your pharmacist for storage details. Keep all medications away from children and pets. Unless instructed to do so, do not flush the medicines in the toilet or pour them into the drain. Properly discard this product when it expires or is no longer needed. Consult your pharmacist or local waste disposal company.

Conclusion 

Amphotericin B is an antifungal drug used for a variety of conditions such as aspergillosis, blastomycosis, etc. The new funguses raised out of covid-19 are also treatable with this medicine. It is given intravenously every 2-6 hours. primarily a test dose is given to analyze if you are tolerable enough for the medicine. As it produces some side effects, it can’t be given blindly to anyone. please consult either with your doctor or pharmacist before taking the dose.

Leave a Reply

Your email address will not be published. Required fields are marked *